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1-Humans get cholesterol from the diet or they syn... Bookmark 1-Humans get chol

ID: 477516 • Letter: 1

Question

1-Humans get cholesterol from the diet or they syn... Bookmark 1-Humans get cholesterol from the diet or they synthesize it from Acetyl CoA. An adult on a low cholesterol diet synthesizes around 600 mg cholesterol per day. This amount drops dramatically if the person transitions to a redmeat diet. Give a mechanistic explanation for this observation!

2-Which diet do you think make a person more prone to generate ketone bodies; a “no-carb diet” or a “no-carb diet” supplemented with glucogenic amino acids such as aspartate and valine? Justify very briefly.

Explanation / Answer

question1-Humans get cholesterol from the diet or they syn... Bookmark 1-Humans get cholesterol from the diet or they synthesize it from Acetyl CoA. An adult on a low cholesterol diet synthesizes around 600 mg cholesterol per day. This amount drops dramatically if the person transitions to a redmeat diet. Give a mechanistic explanation for this observation!

The rate-determining step in the biosynthesis of cholesterol is the synthesis of mevalonate catalyzed by hydroxymethylglutaryl-CoA reductase.

This enzyme issubject to feedback regulation by the negative modulator cholesterol.

the other factors also control HMG-CoA reductase activity in synthesis.

cholesterol synthesis.

is reduced to mevalonate by NADPH.

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