4- Metabolism of propionyl-CoA in humans requires which of the following cofacto

Question

4- Metabolism of propionyl-CoA in humans requires which of the following cofactors?

a) flavin adenine dinucleotide

b) cobalamine (B-12)

c) thiamine pyrophosphate

d) lipoic acid

e) pyridoxal phosphate

5. The enzymes that catalyze the beta-oxidation of fatty acids function in which cellular compartment?

a) endoplasmic reticulum

b) Golgi complex

c) lysosome

d) mitochondrion

e) nuclear envelope

7. Fatty acid synthase:

A. synthesizes only palmitate.

B. yields an unsaturated fatty acid by skipping a reductive step.

C. produces hydroxy fatty acids in nerve tissue.

D. can stop with the release of a fatty alcohol instead of an acid.

E. can produce a branched-chain fatty acid if methylmalonyl CoA is used as a substrate.

Explanation / Answer

4) answer: b) cobalmine (B-12)

Metabolism of propionyl-CoA in humans requires Vitamin B12 as adenosylcobalmine

5) answer: d) mitochondrion

Fatty acid activation happens in the cytosol, they are oxidized inside the mitochondrion cellular compartment.

7) answer: A. synthesizes only palmitate.

Fatty acid synthase is an enzyme, which main function is to catalyze the synthesis of palmitate (To synthesize a long-chain saturated fatty acid from acetyl-CoA and malonyl-CoA, in the presence of NADPH)

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