Glucagon binds to the glucagon receptor, which interacts with amembrane-bound G

Question

Glucagon binds to the glucagon receptor, which interacts with amembrane-bound G protein, whose
subunit releases GDP and binds GTP. The subunit thendissociates from the G protein and diffuses to
a membrane-bound adenylyl cyclase which produces cAMP. In thisscenario, name the (1) transducer,
(2) effector, (3) first messenger, and (4) second messenger.

a) (1) glucagon, (2) cAMP, (3) G protein, (4) GTP
b) (1) G protein, (2) adenylyl cyclase, (3) glucagon, (4) cAMP
c) (1) G protein, (2) GTP, (3 ) glucagon, (4) cAMP
d) (1) glucagon, (2) G protein, (3) adenylyl cyclase, (4) cAMP

Explanation / Answer

According to your explanation , the fourth option D iscorrect. Glucagon binds to its receptor which activates the subunit of G protein which activates adenylyl cyclase whichproduces cAMP.. But if you want to know the transducer of the pathway it isnot glucagon but GTP protein. This is given in the followinglink: http://en.wikipedia.org/wiki/Second_messenger_system In that case it will be as GTP-Adenylyl cyclase-cAMP.In thatcase the second option would be better but glucagon does not serveas a primary messenger. Kindly check the options given.

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