Question 3 Which of the following processes will demonstrate a linear uptake cur

Question

Question 3 Which of the following processes will demonstrate a linear uptake curve as the extracellular concentration of molecules increases?

active transport

receptor-mediated endocytosis

pinocytosis

carrier mediated facilitated diffusion

Question 4 When G proteins activate adenylyl cyclase, the concentration of ___ increases in the cytosol.  

cAMP

Ca++ ATP

DAG and IP3

Question 5 Addition of mannose to lysosomal enzymes happens where in the synthesis process?

cytosol

smooth ER

trans-Golgi network

Rough ER

Question 6 Which of the following statements is TRUE?

All extracellular signaling molecules are transported across the plasma membrane into the cytosol by their receptor.

A cell-surface receptor capable of binding only one natural ligand can mediate only one kind of response.

All hydrophobic signaling molecules bind cell-surface receptors to induce a response.

All hydrophilic signaling molecules bind to cell-surface receptors that contain at least one membrane-spanning domain.

Question 7 When G proteins activate phospholipase C, the concentration of ___ increases in the cytosol.

Ca++

CAMP

ATP

DAG and P3

Question 8 Phosphorylation of mannose residues in the cis-Golgi network is part of the formation process for these organelles.

Rough ER

Lysosomes

Mitochondna

Question 9 Differentiation of neuronal cells from epithelial cells during development is an example of which of the following?

Hormonal signaling

Neuronal signaling

Contact-dependent signaling

Paracrine signaling

Question 10 When a trimeric G protein is activated by a cell-surface receptor___

the BY subunit exchanges its bound GDP for GTP.

It dissociates into an active a subunit and an inactive BY subunit.

It dissociates into a free B subunit and an ay subunit.

The a subunit exchanges its bound GDP for GTP

Explanation / Answer

(3) Active transport

(4) cyclic AMP concentration rises in cytosol upon G-protein activation

(5) They carry a unique marker in the form of mannose 6-phosphate (M6P) groups, which are added exclusively to the N-linked oligosaccharides of these soluble lysosomal enzymes as they pass through the lumen of the cis Golgi network

ref:- http://www.ncbi.nlm.nih.gov/books/NBK26844/

(6) A cell-surface receptor capable of binding only one natural ligand can mediate only one kind of response is true.

(7) The Ca++ concentration increases

(8) The transport vesicles that deliver these proteins to late endosomes (which later form lysosomes) bud from the trans Golgi network.

(9) Paracrine signalling may be responsible for such differentiation

(10) G proteins are composed of three protein subunits

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