A cytoskeletal regulatory protein is found to increase the binding of ATP to act

Question

A cytoskeletal regulatory protein is found to increase the binding of ATP to actin only in its monomeric form, resulting in more ATP-bound actin monomers (which can then form filaments). Increasing the levels of this regulatory protein would probably have the following effect:

a. Destabilize the assembled actin filament ?

b. Prevent actin monomers from binding together to form assemblies ?

c. Increase the rate of actin filament formation from actin monomers ?

d. Stabilize the assembled actin filament ?

e. None of the above ?

Explanation / Answer

a) Destabilize the assembled actin filament by causing depolymerization when its (Thymosin beta 4) concentration level increases

ALSO

b) Prevent actin monomers from binding together to form assemblies. The protein mentioned here is Thymosin beta 4 They tend to sequester the actin monomers. It is known to buffer the concentration of free actin by maintaining a pool of free actin monomers.

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