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Cystic fibrosis is an autosomal recessive disorder. In one population, the frequ

ID: 43624 • Letter: C

Question

Cystic fibrosis is an autosomal recessive disorder. In one population, the frequency of affected individuals (A 2 A 2) is 0.0004. Assuming that this population is under Hardy-Weinberg equilibrium, calculate all allele frequencies and genotype frequencies. Enter your numerical answers in the boxes below. Express each answer to four decimal places. Frequency of the A1 allele = Frequency of the A2 allele = Frequency of homozygous dominant individuals = Frequency of heterozygous individuals = Frequency of homozygous recessive individuals =

Explanation / Answer

The Hardy weinberg formula is as follows:

p+q=1

&

p2+2pq+q2= 1

where p = dominant allele frequency

         q= recessive allele frequency

       2pq= frequency of heterozygous individuals

        p2= frequency of homozygous dominant individuals

         q2= frequency of homozygous recessive individuals

A2A2= 0.0004 (given)

i.e. q2= 0.0004

thus, q= 0.02

q= frequency of recessive allele A2= 0.02

frequency of p (allele A1) = 1-q= 0.98

frequency of homozygous dominant = A1A1 = p2= 0.9604

frequency of heterozygous individuals=2pq= 2X 0.02X 0.98= 0.0392

frequency of homozygous recessive =q2= 0.0004 (given)

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