With age, somatic cells are thought to accumulate genomic \'scars\' as a result

Question

With age, somatic cells are thought to accumulate genomic 'scars' as a result of innacurate repair to double stranded breaks by NHEJ. Estimates based on the frequency of breaks in primary human fibroblasts suggest that by the age of 70 each human somatic cell carry some 2000 NHEJ-induced mutations due to innacurate repair. If these mutations were distributed randomly around the genome, how many genes would you expect to be affected? (Assume 2.5% of the genome is crucial information provided by the genes).

Explanation / Answer

the genome carry 2000 NHEJ induced mutations in each somatic cell (100% of the genome).

2.5% of the genome produces genes. 800 genes will be affected

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