About 1/22,000 babies born in the U.S.have Hunter\'s syndrome, a defect in the p

Question

About 1/22,000 babies born in the U.S.have Hunter's syndrome, a defect in the processing of glycosaminoglycans. It is caused by a defect in a single gene and is inherited as an autosomal recessive. Before the advent of modern medicine, 80% of these children died before adulthood.

a) Assuming that the surviving adults reproduce normally, what is s, the selection coefficient against the recessive allele?

b) Assuming that the frequency of the allele has not changed appreciably since treatment became available, what is your best estimate of the mutation rate from the normal allele to the defective allele?

Explanation / Answer

a) Survival rate is 20%.

Reproductive rate is 4

Relative fitness is 20/20 = 1.0

Calculate the selection coefficient (s) by subtracting each fitness value from 1.0 (that is, s = 1-w).

s = 1-1 = 0

Therefore, the selection coefficient of the recessive allele is 0.

a) Survival rate is 20%.

Reproductive rate is 4

Relative fitness is 20/20 = 1.0

Calculate the selection coefficient (s) by subtracting each fitness value from 1.0 (that is, s = 1-w).

s = 1-1 = 0

Therefore, the selection coefficient of the recessive allele is 0.

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