Which of the following would happen if a drug that blocks the action of DNA poly
ID: 42472 • Letter: W
Question
Which of the following would happen if a drug that blocks the action of DNA polymerases was introduced into cells just prior to infection with a virus with a DNA genome whose late gene expression depends on viral replication?
The virus would not be able to enter the host cell
The newly formed virions would be unable to leave the host cell
No viral proteins would be made and the virus would be unable to replicate
Early viral proteins would be made but the viral genome would be unable to replicate.
aThe virus would not be able to enter the host cell
bThe newly formed virions would be unable to leave the host cell
cNo viral proteins would be made and the virus would be unable to replicate
dEarly viral proteins would be made but the viral genome would be unable to replicate.
Explanation / Answer
D. Early viral proteins would be made but the viral genome would be unable to replicate.
Early viral proteins are necessary for entry of the viral genome into the host cell prior to replication of viral genome whereas late proteins are required for release of viral particles by cell lysis following replication.
DNA polymerase is an enzyme which is responsible for replication of viral DNA. But introduction of drug that blocks the action of DNA polymerases prior to viral infection will not inhibit the production of early proteins and the virus can enter the host cell. But it would prevent replication of genomic DNA of virus and inturn production of numerous virions
Due to inhibition of viral DNA replication synthesis of late proteins will also be prevented.
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