The retinoblastoma gene (rb) encodes a protein that inhibits E2F, a transcriptio

Question

The retinoblastoma gene (rb) encodes a protein that inhibits E2F, a transcription factor that activates several genes involved in cell division. Mutations in rb are associated with certain forms of cancer. Under the following conditions would you expect cancer to occur?

Both copies of rb are functional, one copy of E2F is defective.

2. One copy of rb is defective, both copies of E2F are functional.

Both copies of rb are defective, both copies of E2F are functional.

Both copies of rb are defective, one copy of E2F is defective.

Both copies of rb and E2f are defective.

no

yes

Please EXPLAIN!!!!

Both copies of rb are functional, one copy of E2F is defective.

2. One copy of rb is defective, both copies of E2F are functional.

Both copies of rb are defective, both copies of E2F are functional.

Both copies of rb are defective, one copy of E2F is defective.

Both copies of rb and E2f are defective.

no

yes

Explanation / Answer

botth the copies of rb will be defecttive and both copies of E2F are functional (yes) because as we know that retinooblastooma arises when there are both the rb genes are inactivated, but when the gene are normal they inhit the E2F which causes cell divisions which will cause cancer , so when the genes are mutated they wil activate the E2F which will cause the cell divisions to occur and cause cancer.

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