1.Which of the following statements regarding DNA replication is true ? A) Bacte
ID: 42375 • Letter: 1
Question
1.Which of the following statements regarding DNA replication is true?
A) Bacterial replication is faster than eukaryotic replication.
B) DNA replication during embryonic development occurs at a slower rate than in the early stages of neonatal life.
C) Early-replicating genes are those that are not actively transcribed.
D) The rate of DNA replication is constant at all stages of development in eukaryotes.
E) Cyclin-dependent kinases (Cdk) are not involved in the DNA replication process.
2.DNA replication
A) requires a type of RNA polymerase. B) is partially regulated by promoter/terminator sites.
C) proceeds by making two continuous strands. D) is not edited once polymerization has occurred. E) is totally conservative.
3.Which one of the following is not characteristic of prokaryotic genomes?
A) gene arranged in operons B) distinct replication site
C) presence of introns D) may have histone-like proteins associated with the chromatin E) found in the nucleoid
4. Using polyethylene glycol, a cancer cell and a normal cell are fused. The resulting hybrid behaves like a normal cell. The best reason for this observation is the
A) recombination between cancer and normal chromosomes. B) removal of environmental triggers.
C) high levels of p53 in the normal cell D) high level of myc kinase activities in the normal cell E) C and D
Explanation / Answer
1. A) Bacterial replication is faster than eukaryotic replication,
Because of smaller sized genome, higher rate of bacterial multiplication and elongation.
2. A) requires a type of RNA polymerase.
DNA polymerase requires RNA primer to initiate replication which is synthesized by enzyme DNA primase. But DNA primase is a type of RNA polymerase. Hence DNA replication is dependent on activity of RNA polymerase.
3. C) presence of introns
Introns are non-coding sequences present interspersed in between the coding sequences of eukaryotic genome called exons. They are absent in prokaryotes. These introns are removed and exons undergo alternate splicing in eukaryotes prior to translation in eukaryotes.
4. E) C and D
P53 is a tumor suppressor antigen which inhibits cancer by preventing mutations in the genome. Myc kinase is a transcription factor which can regulate cell cycle and induce apoptosis in cancerous. Hence high levels of p53 and myc kinase restores normal cell activity in a cancerous and normal cell hybrid fused using polyethylene glycol.
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