Question 6 of 8 pling Most eukaryotic genes are normally inactive and require po

Question

Question 6 of 8 pling Most eukaryotic genes are normally inactive and require positive regulation. Determine whether the following are associated with positive regulation (activation) or negative regulation of eukaryotic genes If one of the choices is not a factor involved in regulating transcription, or if a choice does not apply, place it in the "neither" bin. Positive regulation Negative regulation Neither enhancer bound b coactivator bound to DNA transcription factor(s transactivator interacts mediator detaches from RNA polymerase ll with histone acetyltransferases (HATs) euchromatin digestion by DNase creased histone deacetylase activity Map A

Explanation / Answer

Transactivator binds to HAT - positive regulation

Mediator detaches from RNA polymerase 2 - positive regulation. The mediator acts as an activator

Euchromatin - positive regulation. IT is the part of genome frequently transcribed.

Digestion by DNase - neither

Increased histone deacetylase - negative regulation. Deacetylation makes histones bind more tightly to DNA and prevent transcription

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