Two curly-winged Drosophila flies are mated and produce an F1 generation that co

ID: 41895 • Letter: T

Question

Two curly-winged Drosophila flies are mated and produce an F1 generation that consists of 341 curly-winged flies and 162 normal flies. Explain the inheritance pattern involved in this situation. What evidence do you have to support your claim? Hemoglobin is constructed of four protein subunits, two subunits are referred to as alpha-globin and two as beta-globin Sickle-cell anemia is a debilitating genetic disease caused by the presence of two Hbs alleles. A mutation of a the HbA allele changes to the Hbs allele. What genetic change creates the Hbs allele What are three terms that could be used to describe/classify this mutation? Compare phenotypes at the molecular, cellular, and orgamsmal levels for individuals who are homozygous for the normal hemoglobin allele (HbA HbA) and the sickle-cell allele (Hbs Hbs Samuel and Amanda do not have sickle-cell anemia, but both have older siblings with sickle-cell anemia They have watched their siblings suffer from sickle-cell disease all their lives. Symptoms include joint pain, swollen hands and feet, shortness of breath, and eye problems. This phenotypic pattern is known as If Samuel and Amanda marry and have children, what with sickle-cell disease? is the chance that they will have a child

Explanation / Answer

Curly winged gene should be a dominant gene over the normal winged gened thats the reason the particular ratio of phenotypes produced. Curly winged progeny(341) is more than the normal winged progeny thats why the gene is dominant to the normal winged gene

3A) Hbs allele was produced based on single aminoacid substitution, Valine was substituted for glutamic acid at the sixth position of the beta chain, due to a point mutation

3B) here a base substitution or point mutation occurs which results in change of amino acids by the change of a codon. change of codon in some cases will result in same amino acids which do not change the protein called as silent mutation. In another case a change of codon will introduce a stop codon which will be called as nonsense mutation.

HbAHbA

HbSHbS

MOLECULAR

Homozygous unaffected

Homozygous affected

CELLULAR

Normal blood cell

Sickle cell blood cell

ORGANISMAL

Normal individual

Sickle cell anaemic individuals

The phenotypic pattern is called as CARRIER and AFFECTED individuals

One progeny out of 4 progenies will be sickle cell phenotype. 2 progenies will be carrier and one progeny will be normal

Ratio will be 1:2:1(Phenotypic ratio)