Which of the following proteins would NOT contain a signal sequence? DNA polymer

Question

Which of the following proteins would NOT contain a signal sequence?

DNA polymerase, which resides in the nucleus

hexokinase, which resides in the cytoplasm

cytochrome c, which resides in the mitochondria

Basigin, which is a plasma membrane-embedded protein

I'm thinking B - becuase it's in the cytoplasm

DNA polymerase, which resides in the nucleus

hexokinase, which resides in the cytoplasm

cytochrome c, which resides in the mitochondria

Basigin, which is a plasma membrane-embedded protein

Explanation / Answer

Based on the given data, the correct option is (b) hexokinase (HK), which resides in the cytoplasm. The expression of hexokinase takes place in cytoplasm, hence it does not have to transport to any organelle. So, it does not contain any signal sequence. Apart from this HK is homeotic gene, therefore it express in all cell types and cell organelles, if necessary.   

After translation, the DNA polymerase must transport into the nucleus, hence it has a nuclear localization signal (NSL). So, the option (a) is incorrect. Likewise, cytochrome c and plasma membrane-embedded protein also have signal sequences. Thus, the option (c) and (d) are also incorrect.

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