The following is a pedigree that shows the inheritance of a rare completely pene
ID: 40523 • Letter: T
Question
The following is a pedigree that shows the inheritance of a rare completely penetrant autosomal dominant disorder. DNA samples from generations I, II, III and IV were obtained and subjected to RFLP analysis. The results of the analysis are shown below. The RFLP marker used for the top panel is marker #135, and the one used for the bottom panel is marker #219, both in chromosome 17.
Question 1:
c) If individuals III-4 and III-5 decide to have one more child, what are the odds that this child would have the disorder, just based on the genotypes of the parents and the inheritance pattern of the disorder?
The following is a pedigree that shows the inheritance of a rare completely penetrant autosomal dominant disorder. DNA samples from generations I, II, III and IV were obtained and subjected to RFLP analysis. The results of the analysis are shown below. The RFLP marker used for the top panel is marker #135, and the one used for the bottom panel is marker #219, both in chromosome 17. Question 1: c) If individuals III-4 and III-5 decide to have one more child, what are the odds that this child would have the disorder, just based on the genotypes of the parents and the inheritance pattern of the disorder?Explanation / Answer
The given disease follows autosomal dominant ihheritance pattern. In this, the male and female offspring will be affected equally. In this case both parents are heterozygous. If individuals III-4 and III-5 decide to have children, the probability to have affected children is 3/4.
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