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6) Which of the following is true of the Na^+-l^- symporter? A) Requires ATP ind

ID: 39997 • Letter: 6

Question

6) Which of the following is true of the Na^+-l^- symporter? A) Requires ATP indirectly B) Requires Na^+ gradient C) Increases its activity in the presence of TSH D) All of the above E) Only B and C 7) Thyrotropin releasing hormone (TRH) signals through what type of receptor? A) G protein coupled receptor that signals through phospholipase C to release Ca+2 B) G protein coupled receptor that reduces cAMP production C) A cytosolic/nuclear receptor that dimerizes and inhibits gene transcription when not bound to TRH D) A cytosolic/nuclear receptor that dimerizes and activates gene transcription when bound to TRH E) Both C and D

Explanation / Answer

6. Na+ - I- symporter (NIS) requires electrochemical gradient of sodium ions (the intracellular concentration of sodium is approximately 12 mM and extracellular concentration 140 mM). The activity of NIS is increased in presence of TSH. Hence option E is correct.

7. The TRH receptor is a G - protein coupled receptor acting through the Phospholipase C and is found in brain. Option A is correct.

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