Which of the following statements comparing the targeting of a mitochondrial mat

Question

Which of the following statements comparing the targeting of a mitochondrial matrix protein to the targeting of a protein to the ER is/are correct? Choose all that apply.

-Insertion of proteins into both compartments takes advantage of an energy source in the form of an electrochemical gradient.

-Proteins destined for either compartment are likely to retain their amino terminal targeting signals.

-Proteins translocated into either compartment have an equal chance of ultimately being localized to the outside of the cell.

Explanation / Answer

-Proteins translocated into either compartment have an equal chance of ultimately being localized to the outside of the cell.-FALSE

Insertion of proteins into both compartments takes advantage of an energy source in the form of an electrochemical gradient.FALSE

-Proteins destined for either compartment are likely to retain their amino terminal targeting signals.FALSE

Insertion of proteins into both compartments takes advantage of an energy source in the form of an electrochemical gradient.FALSE

-Proteins destined for either compartment require sequences of amino acids which serve as targeting signals.TRUE -Proteins destined for either compartment are inserted into their respective compartments in an unfolded state. FALSE -The same signal can be used to direct a protein to either compartment, as long as the appropriate receptor recognizes the signal.FALSE -Proteins destined for either compartment are allowed to fold in the cytoplasm and then are unfolded prior to insertion into their respective compartments.TRUE

-Proteins destined for either compartment are likely to retain their amino terminal targeting signals.FALSE

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