2. Consider the following aligned 13-mer DNA sequences: GGGAAATGCGTCA TGTTCATGGC
ID: 3811 • Letter: 2
Question
2. Consider the following aligned 13-mer DNA sequences:GGGAAATGCGTCA
TGTTCATGGCTTG
GAAGCATGACTCT
GAAATATGAGGGA
GAATCATGGAATG
ATAAGATGGCCCA
TGGAAATGGCCGC
CAAAGATGCGCTG
AATTAATGACATT
TTTGCATGAGGCG
How many of each bases appear at each position?
#A :_ _ _ _ _ _ _ _ _ _ _ _ _
#C :_ _ _ _ _ _ _ _ _ _ _ _ _
#G :_ _ _ _ _ _ _ _ _ _ _ _ _
#T :_ _ _ _ _ _ _ _ _ _ _ _ _
If these bases appeared at random each should appear 2.5 times ineach position. At
which positions are the same bases present 5 or more times?
What would you suggest is the consensus sequence?
_ _ _ _ _ _ _ _ _ _ _ _ _
Explanation / Answer
1 2 3 4 5 6 7 8 9 10 11 12 13 G G G A A A T G C G T C A
T G T T C A T G G C T T G
G A A G C A T G A C T C T G A A A T A T G A G G G A
G A A T C A T G G A A T G
A T A A G A T G G C C G C
C A A A G A T G C G C T G
A A T T A A T G A C A T T
T T T G C A T G A G G C G #A :2_ 5 5_ 4_ 2 _ 9_ 0 _ 0 _ 4 _ 1_ 2_ 0_ 2
#C :1_ 0_ 0_ 0 _ 4_ 0_ 0_ 0 _ 4 _ 2_ 3 _ 3 1
#G :4_2_ 1_ 2_ 2_ 0_ 0_ 9_ 3_ 4 _2_ 2_ 4_
#T :2_ 2_ 3_ 3_ 3 _ 0_ 9_ 0_ 0_ 0 _ 3_ 4_ 2_
At position 2 and 3 thebase A is present 5 times and at position 6 it ispresent 9 times. At position 8 base base G is present 9 times and at position 7 base T ispresent 9 times. The consensus sequence isa way of representing the multiple sequence alignment. The consensus sequence forthis may be as: N(CCC)NNATG(T)N(A)N
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