Family B pedigree for non-syndromic deafness. Filled symbols represent affected

Question

Family B pedigree for non-syndromic deafness. Filled symbols represent affected individuals and open symbols represent unaffected individuals [the inheritance pattern for non-syndromic deafness in Family B is known to be autosomal dominant. what is the probability that Male VII-7 could father 3 unaffected children with his wife, who is heterozygous for the deafness gene? A. 0 B. 1/64 = 0.016 C. 3/4 = 0.75 D. 1/12 = 0.083 Family A pedegree shows hearing disorder. I need help to know how to do this problem. Thanks

Explanation / Answer

Since non-syndromic deafness is autosomal dominant presence of only one copy of dominant allele carrying the gene for disorder is sufficient for affecting the individuals.

In this case there are two possibilites:

Possibility 1: When father is heterozygous

Let CD be the dominant allele for non-syndromic deafness and Cd be the recessive allele for non-syndromic deafness.

Genotype of affected father would be CD Cd and that of heterozygous mother would be CD Cd. The gametes released, genotype and phenotypes of the offsprings are represented in the Punnet

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