Questions 12 through 15 A B C D E Substrate ---- NAD + -- FMN--CoQ -- Cyto b---

Question

Questions 12 through 15

                         A             B          C               D                             E

Substrate ---- NAD+-- FMN--CoQ -- Cyto b--- Cyto c -- Cyto a & a3 --- O2

(reduced)

                                     ATP                    ATP                                           ATP

Match the following inhibitors with their site-specific location.

12 Amytal Rotenone B

13-Antimycin A D

14-Sodium azide E

15-CN- E

17 Which of the following statements is INCORRECT regarding oxidative phosphorylation and substrate level phosphorylation?

A) The process of oxidative phosphorylation refers to the electrochemical gradient used for the synthesis of the high energy bond of ATP

b) Oxidative phosphorylation is an example of an aerobic pathway

c) Substrate level phosphorylation is particularly important for converting fuel energy to ATP in red blood cells

d) Oxidative phosphorylation stops if oxygen is removed

e) The generation of ATP during the conversion of glucose to lactate is an example of oxidative phosphorylation

18- Which of these statements are TRUE?

a) Because NADH enters the electron transport chain at complex I, energy is released from the oxidation of NADH to synthesize three ATP.

b) Since FADH enters the chain at a lower energy level at complex II, it only provides energy to drive the synthesis to produce two ATP.

c) The NADH produced in glycolysis cannot pass through the mitochondrial membrane to the electron transport chain.

d) The hydrogen ions and electrons from NADH in the cytoplasm are transferred to compounds that can enter the mitochondria.

e) In the glycerol shuttle system, dihydroxyacetone phosphate, a compound in glycolysis that can enter the mitochondria, is reduced to glycerol-3- phosphate and NAD is regenerated

f) After glycerol-3-phosphate crosses the mitochondnal membrane, the hydrogen ions and electrons are transferred to FAD.

g) FADH is produced along with glycerol-3-phosphate, which returns to the cytoplasm. h) The overall reaction for the glycerol-3-phosphate shuttle is

NADH            + H+ +   FAD-

Explanation / Answer

12 Amytal Rotenone :B ( Blocks the ubiquinone binding site)

13-Antimycin : D (Binds to cytochrome C)

14-Sodium azide :E (Binds to cytochrome C oxidase)

15-CN :E (Binds to cytochrome C oxidase)

17. e

18. i

19. F

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