17. Remembering that the wobble base of the tRNA is the 5? base of the anticodon

Question

17. Remembering that the wobble base of the tRNA is the 5? base of the anticodon: a. In human tRNAs, what are the sequences of all possible anticodons that were originally transcribed with A in the wobble position? (Assume this A is always modified to I.) b. In human tRNAs, what are the sequences of all possible anticodons that were originally transcribed with U in the wobble position? C. How might the wobble Us in each of the anticodons in (b) be modified and still be consistent with the genetic code? d. What is the theoretical minimal number of different tRNA genes that must exist in the human genome? (Assume that xo^5 U pairs with A, G, or U only.)

Explanation / Answer

17)

Based on the given data,

a)

The some possible sequences of all possible anticodons are:

b)

The some possible sequences of all possible anticodons are:

D)

The theatrical minimum value would be 20 corresponding to the number of different amino acids incorporated into proteins. The maximal value would be 61 (64-3), since no tRNA exist for the three stop codons.

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