In the mitochondira there is an R lactate dehydrogenase that unlike the cytoplas

Question

In the mitochondira there is an R lactate dehydrogenase that unlike the cytoplasmic enzyme uses cytochrmoe c as an oxidizing agen and D lactate as a substrate. The prduct, pyruvate is the same for both enzymes. Given that the reduction portential of cytochrmoe c is 0.235 v at ph 7.

cyto-c[Fe+3] +e-= cyto-c[Fe+2].... and the reduction potential of pyruvate to F lactate is identical to that of L-Lactate.

IF this reaction is carried out at ph 7.8 rather than at ph 7 how will the equilbrium constant for mitochondiral LDH reaction change. BE QUANTITATIVE!!

Explanation / Answer

Mitochondria occupy a substantial portion of the cytoplasmic volume of eucaryotic cells, and they have been essential for the evolution of complex animals. Without mitochondria, present-day animal cells would be dependent on anaerobic glycolysis for all of their ATP. When glucose is converted to pyruvate by glycolysis, only a very small fraction of the total free energy potentially available from the glucose is released. In mitochondria, the metabolism of sugars is completed: the pyruvate is imported into the mitochondrion and oxidized by O2 to CO2 and H2O. This allows 15 times more ATP to be made than that produced by glycolysis alone.

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