The following are descriptions regarding the progressive approach for multiple s
ID: 3683359 • Letter: T
Question
The following are descriptions regarding the progressive approach for multiple sequence alignment used in Clustal algorithm. Put the statements in the correct order, such that they are in the right order in the Clustal algorithm. A- The already aligned sequences are converted into a consensus sequence. A pair wise alignment is conduct for very possible pair of sequences using the Needleman Wunsch algorithm A distance matrix is generated. A guide tree is created using the information in the distance matrix. Additional sequences are added to the already aligned sequences by aligning to the consensus sequence using the Needleman Wunsch algorithm, with gaps at fixed positions. The pair of most similar sequences is realigned first with the Needleman Wunsch algorithm.Explanation / Answer
the right order of the clustal algorithm is :
(B) A pairwise alignment is conducted for every possible pair of sequence using the Needleman Wunsch algorithm.
(C) A distance matrix is generated.
(D) A Guide tree is created using the information in the distance matrix.
(F) The pair of most similar sequences is realigned first with the Needleman Wunsch algorithm.
(A) The already aligned sequences are converted into a consensus sequence.
(E) Additional sequences are added to the already aligned sequences by aligning to the consensus sequence using the Needleamn Wunsch algorithm, with gaps at fixed positions.
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