GTP-binding to the alpha subunit of a heterotrimeric G protein causes ( select a
ID: 36802 • Letter: G
Question
GTP-binding to the alpha subunit of a heterotrimeric G protein causes (select any/all answers that apply):
A.
the alpha subunit to dissociate from the beta/gamma dimer.
B.
the beta subunit to dissociate from the gamma subunit.
C.
all three G protein subunits to dissociate from one another.
D.
the heterotrimeric G protein to dissociate from the GPCR.
E.
the alpha subunit to dissociate from its effector molecule.
A.
the alpha subunit to dissociate from the beta/gamma dimer.
B.
the beta subunit to dissociate from the gamma subunit.
C.
all three G protein subunits to dissociate from one another.
D.
the heterotrimeric G protein to dissociate from the GPCR.
E.
the alpha subunit to dissociate from its effector molecule.
Explanation / Answer
hello,
am a 3rd year medicine student
A. the alpha subunit dissociate from the beta/gamma dimer
when gtp binds to alpha beta/gamma dimer, the dimer leave the receptor on the membrane and bind to an enzyme to activate it, this mechanism is used in many pathways in the cell and usually is a slower mechanism than other types of receptor activating pathways ( for example ion channel pathway is a faster one), the last stage of this pathway is that gtp will be converted to gdp and phpsphate ion plus energy that has been used in this mechanism.
thank you, i know its a bit not ordered but i hope some of this would help
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