A woman has chronic bladder infections that eventually lead to scarring of the b

Question

A woman has chronic bladder infections that eventually lead to scarring of the bladder with increased deposition of collagen within the bladder wall. This in turn leads to a decrease in bladder wall compliance. Assume the infection is now gone, but the increased bladder wall collagen deposition and decreased compliance remain.

       Describe the resulting urinary symptoms of decreased compliance. For each resulting urinary symptom, you must also explain why the symptoms are experience by the female patient.

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Explanation / Answer

The collagen and elastin fibres as they provide structural support to the smooth muscles of the bladder to further stretch during blaaddder expnsion. so, the amout and the conformational orientation off the collagen ffibres re important afor proper bladder functioning .

Since the lower urinary tract symptoms (LUTS) are associaated with the increased deposition of ECM(extracellular matrix) which results sin thickening of the ssmooth muscle , improper emptying of the bladdder therefore leding to chronic fibrosis and even after the treatment is given and disease is cured, the symptoms still lies inside the paitent body.

This increase in deposition further leads to the decreased bladder compilance due to the increased intravesical pressure in smooth muscle , as compilance is nothing but just the relationship of pressure to volume. since the volume is increased because of improper emptiness of the bladder and thickening of walls whereas the pressure is decreased which results in a small value. Therefore, compilance is low.

Refernce:1. ICS 2018 FLORENCE: W8: chronic fibrosis in LUT dysfunctions- mechanism and therapeutic options.

2. structural changes of urinary bladder after chronic fibrosis.

3. the clinical significance of urinary compilance.

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