KARA Kara is a 25 year old woman entering the hospital with persistent diarrhea
ID: 3522052 • Letter: K
Question
KARA Kara is a 25 year old woman entering the hospital with persistent diarrhea and abdominal pain. An upper gastrointestinal radiologic series suggests the presence of a duodenal ulcer, which is confirmed by endoscopy. Kara's basal rate of secretion of gastric HCl is about 12 mmole/hr mmole/hr). Kara's serum gastrin is 1145 pg/ml (the normal range is 50 to 150 pg/ml). When Kara's gastric juice is removed by nasogastric tube during a 24 hour period, the diarrhea is corrected. Kara also has moderate steatorrhea (excess fat in the stool) (the normal range is 1 to 5 What is the role of gastrin on HCI secretion? Where is gastrin produced, and what stimulates its production? a the endoscope. Examination of the mucosal A sample of the mucosa of Kara's stomach fundus is taken vi specime n reveals that the gastric glands are more numerous than normal and have a higher density of Based on the anatomical information given above, what is the most likely reason this patient has such a high basal rate of gastric HCI secretion? parietal cells than normal. 3. 4. Why does Kara have symptoms of an ulcer?Explanation / Answer
Answer 3. Parietal or oxyntic cells secrete HCL ( Hydrochloric acid ) that maintains acidic
condition in the stomach for the digestion of protein. So, the if the endoscopic
sample reveals that mucosal epithelium has more numerous gastric gland and
more dense parietal cells tha normal range, this condition rises basal HCL
secretion rate.
Answer 4. Kara has symptoms of stomach ulcer because Kara has persistent diarrhoea &
stomach pain that caused by oversecretion of HCL.
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