HELP PLEASE , I do not need a Power Point but help me write things to discuss on

Question

HELP PLEASE , I do not need a Power Point but help me write things to discuss one of these articles.

Look over this short list of current research papers:

Simonson TS, Yang Y, Huff CD, et al. Genetic Evidence for High-Altitude Adaptation in Tibet. Science. 2010;329:72-75.

Riquelme CA, Magida JA, Harrison BC, et al. Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth. Science. 2011;334:528-531.

Jordt S, Basbaum AI, Julius D, et al. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007;448:204-208.

Chandrashekar J, Yarmolinsky D, Buchholtz Lv, et al. The Taste of Carbonation. Science. 2009;326:443-445.

Stirling I, Lunn NJ, Iacozza J. Long-Term Trends in the Population Ecology of Polar Bears in Western Hudson Bay in Relation to Climatic Change. Arctic. 1999;52:294-306.

For the final project, you will choose one paper to read, interpret, and relate to the material of the course. You may use lecture material, your laboratory studies, and references provided in the research paper in your interpretation. You will prepare an original PowerPoint presentation that summarizes your interpretation, how the research relates to your study of Human Physiology, and list of references. You will also pose two questions for future research on this topic. The PowerPoint presentation should be between 5 and 7 slides in length and include notes. Your final project is due by the end of Week 16. Your submission will be assessed based on the following: The Final Project is based on your reading and understanding of a recent research paper that casts new light on the physiologic principles you have studied in the course. The assignment consists of putting together a PowerPoint show (about 5-7 slides) that explains the research in the paper you have chosen, and clearly relates it to the material presented in the course. The first part of the grading analysis focuses on meeting all parts of the assignment. Did you submit a PowerPoint show within the time limits of the assignment? Is it of an appropriate length? Does the submission show evidence that you read and understood the paper? Are there citations in the submission to demonstrate further research and application to the problem? The PowerPoint show should incorporate images from the paper (and course) where appropriate to illustrate both the findings of the paper and how those findings might affect what we know about human physiology. It will not be sufficient to merely summarize the research in the selected paper; the findings must be interpreted in light of what has been learned in the course. You are being asked to extrapolate your understandings from human systems to other animals (some of them specialists), and to consider what findings from these other animal systems might mean for our knowledge of how humans work. The work on the project must be your own; phrases and images from the paper (and the course) must be correctly referenced (using AMA). You should use references from the research paper itself, but may also add material from further library research.

Explanation / Answer

TRPM 8 principal detector of environmental cold

The quest for finding specialised molecules which detect changes in temperature arose after finding that dorsal root ganglion respond to heat in the absence of specialized nerve endings. Two families of membrane proteins have been implicated in this

Temperature-activated transient receptor potential ion channels (Trp) belongs to first class. Trpm is one of the subclass of Trp where M in the former stands for melastatin. Trpm family consists of eight different channel TRPM1 to TRPM8.

The paper here talks about Trpm 8 principal detector of environmental cold.

TRPM8 is also called cold and menthol receptor 1 is the primary molecular transducer of cold somatosensation. The paper has stated that though there is a widespread agreement that TRPM8 is indeed involved in detecting cold sensation it is published to remove the ambiguity whether it is principle detector of cold sensation. Some studies have stated that there are more critical excitatory or inhibitory channel for this sensory modality like inhibition of background potassium conductance etc.

The author have generated TRPM8 deficient mice through deletion of genomic region . The resulting TRPM8 mice were normal in overall appearance and viability, and matings between heterozygous animals produced siblings with normal mendelian distributions for gender and genotype.

Sensory ganglia from TRPM8-deficient mice appeared anatomically normal. Functional disruption of the TRPM8 gene was assessed by using live-cell calcium imaging to measure the sensitivity of trigeminal and dorsal root ganglion neurons to cooling agents.

TRPM 8 deficient mice showed normal response to capsicin and allyl isothiocyanate wheras it showed a profound reduction in both the number and magnitude of cellular cold responses.

Behavioural cold sensitivity was assessed by acetone induced evaporative cooling and ability to discriminate between warm and cold surface.

TRPM8-deficient mice retain a small, but finite number of coldsensitive neurons showing a small residual population of cold-sensitive C and AM units. Moreover the animal showed aversion below 15 degree which means TRPM 8 independent pathways are also there but they are not primary pathway,

Thus this paper talks about TRPM8 being primary detector of environmental cold and proved it by conduting experiments on TRPM8 deficient mice.

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