1) Why would t-PA’s not be given to a patient that suffered from a hemorrhagic s
ID: 3520710 • Letter: 1
Question
1) Why would t-PA’s not be given to a patient that suffered from a hemorrhagic stroke? 2) Which drug, COX inhibitors or t-PA’s is used prophylatically to prevent formation of clots? 3) How does the anti- coagulant heparin prevent blood from clotting? 1) Why would t-PA’s not be given to a patient that suffered from a hemorrhagic stroke? 2) Which drug, COX inhibitors or t-PA’s is used prophylatically to prevent formation of clots? 3) How does the anti- coagulant heparin prevent blood from clotting? 2) Which drug, COX inhibitors or t-PA’s is used prophylatically to prevent formation of clots? 3) How does the anti- coagulant heparin prevent blood from clotting?Explanation / Answer
1) t-PA ;
It is a medication that dissolves the Blood Clots. Called as TISSUE PLASMINOGEN ACTIVATOR or THROMBOLYTIC AGENT or more commonly refered as the CLOT BUSTER.
Whats its Use;
It works by improving the flow of blood to the brain which is deprived of blood flow due to the formation of clot.
Method of Medication ;
It is given as an IV ( intravenous) therapy usually through a catheter that is inserted into the vein in arm.
When should be t-PA given;
It should be given within the first three hours or max. of 4 hrs (in selective patients) of the time when the symptoms early started.
Can t-PA b given to all patients..;
Surprising the answer is NO. It is given to patients who have had an Ischemic Stroke ( non-hemorrahagic) as it is the only FDA approved treatment for acute ischemic strokes currently. But the major risk is of BRAIN or Other hemorrhages. It occurs in 1 of every 16 cases which are treated with t-PA , but still its effectiveness can be cancelled out.One might have to clear few things first , they are;
2) Not t-PA's because they are used as the treatment after the turmoil. They cant be taken on daily or regular basis on terms of medication. t-PA's are the clot busters not preventers. But definitly COX (cyclooxygenase) inhibitors can do the work for you. The major example of COX inhibitor is Aspirin, it cause several different effects also like reduction in inflammation, analgesic , reductio in fever etc and not to forget prevention of blood clotting. Aspirin actully has the ability to suppress the production of prostaglandin and thromboxanes due to its irreversible inactivation of COX enzyme.
3)Heparin is the naturally occuring blood anti-coagulant , it is also known as Unfractionated heparin (UFH) , which is produced by basophils and mast cells. Otherwise can be injected for therapeutic dosage. It is the blood thinner which is used to prevent deep vein thrombosis, pulmunary embolism and even arterial thromboembolism. Even treatments for heart attack and Unstable angina is done on basis of heparin. Other uses are in kidney dialysis machine and inside the test tube. Like we discussed about t-PA's Heparin doesnt work in that sense, it doesnt break/burst the clot but actully allows the body's natural clot lysis mechanism to work at the site of junction .
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