. Sickle-cell anemia is a genctic disease. The Sickle-cell allele is recessive,

Question

. Sickle-cell anemia is a genctic disease. The Sickle-cell allele is recessive, but iisea with the homozygous recessive genotype (ss) often die prematurely This affects approximately 16% of the population in Africa. (16 points due to the disease. The frequency of the recessive allele in the population. (3 points) a. b. The frequency of the dominant allele in the population. (3 points) c. The frequency of homozygous dominant individuals in the African population. G points) d. The frequency of heterozygous individuals in the African population. (3points) Based on this analysis, is the African population in Hardy-Weinberg equilibrium? Justify your answer. (4 points) e.

Explanation / Answer

a, frequency of homozygous recessive individual 'ss', q2 = 0.16

=> q= 0.4

th frequency of the recessive allele "s" =0.4

b. frequency of dominant allele "S" , p = 1-q=1-0.4=0.6

c. frequency of homozygous dominant individual SS=p2 =0.36

d. frequency of heterozygous dominant individual Ss=2pq=2x0.4x0.6 = 0.48

e. yes it is in H-W equilibrium.

though p2+2pq+q2 = 0.36+0.48+0.16 = 1

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