Marie Curie was a famous French-Polish scientist known for her pioneering resear

Question

Marie Curie was a famous French-Polish scientist known for her pioneering research on radioactivity. Her work not only brought her fame but her death as well; she developed aplastic anemia due to radiation exposure. She experienced recurrent and prolonged infections (viral, bacterial, parasitic, and fungal). Explain why she suffered from recurrent infections. Be sure to mention the different types of WBC and the relation to the various infections, and the reasons why she lacked the cell-mediated and the humeral response.

Be detailed in your explanation and support your answer with facts from your textbook, research, and articles from scholarly journals. In addition, remember to add references in APA format to your posts to avoid plagiarism.

Explanation / Answer

Aplastic anaemia is a hematologic condition characterized by reduced levels of all types of blood cells (including the WBCs). Aplastic anemia = Bone marrow failure and it is a rare disease characterized by damage to bone marrow and hematopoietic stem cells. This leads to a deficiency of RBC, WBC, and platelets. In disease condition, fat replaces bone marrow cells. It can be caused by exposure to harmful chemicals or by autoimmune deficiencies. As we know that lymphocytes and macrophages are major components of the immune system, aplastic anemia is characterized by compromised immune system function.

Aplastic anemia is characterized by an imbalance in lymphocyte activation either as a result of bone marrow failure or as a contributing factor. Hence the first line treatment includes immunosuppression. Patients with this disease typically show reduced reticulocyte count. Treatment includes Hematopoietic stem cell transplantation and immune suppression.

Marie curie died of aplastic anaemia, which is caused by excessive exposure to radiation, So, the haematocrit value decreases due to the abnormally low RBC levels. The symptoms of Marie Curie are due to the deficiency of RBC (paleness, fatigue, and rapid heart rate), WBC (easy bruising, prolonged bleeding from cuts).

As her blood group is A negative, she can receive blood from A negative and O negative individuals. Because the transfusion with other blood groups causes agglutination reaction.

She experienced recurrent and prolonged infections (viral, bacterial, parasitic, and fungal). Explain why she suffered from recurrent infections. Be sure to mention the different types of WBC and the relation to the various infections, and the reasons why she lacked the cell-mediated and the humeral response.

During the process of cell-mediated and the humeral response the immune cells plays a key role. The immune cells identify and destroy the foreign particles and produce memory cell for those particular microbes. Due to the loss of immunity Marie curie experienced recurrent and prolonged infections (viral, bacterial, parasitic, and fungal).

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