Answer in terms of True (T) or False (F) and explain why: a. Human Beta-cardiac

Question

Answer in terms of True (T) or False (F) and explain why:

a. Human Beta-cardiac myosin binds ADP more tightly when bound to actin than does alpha-cardiac myosin. ?(T/F)?

b. Myosin binding protein C is hypothesized to destabilize the OFF state of the thick- filament. (T/F)?

c. Myosin binding protein C desensitizes the thin-filament to calcium. (T/F)?

d. Phosphorylation of Myosin Binding Protein C by Protein Kinase A increases the probability that Myosin binding protein C will bind to Cardiac Myosin. (T/F)?

Explanation / Answer

a. True

Beta cardiac myosin binds more tightly than alpha cardiac myosin due to maximum activity.

b. True

off state- thick and on state-thin filament.

c. True

desensitizesthin filament.

d. True

binds to thick filaments of cardiac myosin.

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