1-Why would an anesthetic cause a voltage gated sodium channel to open indefinit
ID: 3518023 • Letter: 1
Question
1-Why would an anesthetic cause a voltage gated sodium channel to open indefinitely after the first action potential? 2-if repolarization is extended longer than normal, A) why would the k ions become depleted more quickly from inside which causes the nerve cell to be unable to conduct an action potential after it loses k concentration gradient? B) why after the first action potential, a second one can't be quick as it could normally?1-Why would an anesthetic cause a voltage gated sodium channel to open indefinitely after the first action potential? 2-if repolarization is extended longer than normal, A) why would the k ions become depleted more quickly from inside which causes the nerve cell to be unable to conduct an action potential after it loses k concentration gradient? B) why after the first action potential, a second one can't be quick as it could normally?
2-if repolarization is extended longer than normal, A) why would the k ions become depleted more quickly from inside which causes the nerve cell to be unable to conduct an action potential after it loses k concentration gradient? B) why after the first action potential, a second one can't be quick as it could normally?
Explanation / Answer
1. Anaesthetics basically work by inhibiting the Na+ channel function. Normally the act by inhibiting them such that no as such stimulation is produced. However in some states it may cause permanent Depolarization of the membrane such that no further stimulus can be produced as such no ion exchange possibility is available and thus no stimulus is created.
2. A. In repolarization the K+ channels and Na+ channels are. Open. This causes efflux of ions and thus the inner becomes more negative and outside is more positive. It further leads to hyperpolarization- such that now no potential can be generated for a specific time.
B. The second one can't be quickly produced as the membrane needs time to generate stability and prepare itself for re impulse. This occurs by sending out Na+ back and making the inner more negative.
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