1. Fateema (F/20) was a young Thai girl living in a suburban area of Bangkok in
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Question
1. Fateema (F/20) was a young Thai girl living in a suburban area of Bangkok in Thailand. She was planning to marry Chaiwat (M/25) in the near future. They undertook premarital medical check-up in a large medical clinic in the city centre. The complete blood count indicated that she was anaemic while Chaiwat was not. She requested that her whole family be also checked. The following table shows the laboratory test results (complete blood pictures and some follow-up tests) of her whole family and Chaiwat. Fateema's Fateema sbrother Fateema's Fateema's father Units Chaiwat Fateema sister mother F/20 M/14 M/25 6.26 0.43 68.2 F/18 M/48 F/45 5.51 10.8 0.35 4.09 11.5 0.35 4.35 14.0 ×1012/L g/dL 4.51 RBC ?? Hct 5.51 10.8 0.35 0.39 41 MCV MCH MCHC 32.6 RDW 64.2 19.6 30.5 15.3 87.1 64.2 19.6 30.5 15.3 94.3L 32.2 Pg 85.3 22.2 15.4 2.3 0.6 33.0 15.6 12.6 12.4 du Retic 2.7 3.0 HbF* HbA230.5 0.6 2.7 Chaiwat Fateema Fateema's sister Fateema's brother Fateema's father Fateema's mother The levels of HbF and HbA were measured using high-performance liquid chromatography (HPLC). The following questions refer to the laboratory results of Fateema and her family: (a) On the basis of red cell indices, what is the morphological type of anaemia that Fateema had? What is her mostly likely diagnosis? Explain. 1 mar (b) Which particular type of high-performance liquid chromatography (HPLC) was used for measuring (4 marks) the levels of HbF and HbA Briefly explain its principle and state its advantages. (c) Identify the two family members who had normal complete blood picture (d) What is the single major red cell morphological alteration for Fateema's sister? What is her most (1 mark) likely diagnosis? Explain. (1 mark) (e) Taking into account all laboratory findings, what do you think is the most likely diagnosis for Fateema's father? Explain. (3 marks)Explanation / Answer
A)fateema has beta thalassemia minor.
Low mcv with normal rdw with hba2 slight increase indicates beta thalessemth minor.
B.cation exchange chromatography
Cation exchange chromatography is a form of ion exchange chromatography (IEX), which is used to separate molecules based on their net surface charge. Cation exchange chromatography, more specifically, uses a negatively charged ion exchange resin with an affinity for molecules having net positive surface charges. Cation exchange chromatography is used both for preparative and analytical purposes and can separate a large range of molecules from amino acids and nucleotides to large proteins. Here, we focus on the preparative cation exchange chromatography of proteins.
C) fateema brother and mother.
D)elliptocytosis
Elliptocytes Ovalocytes Cells have rod, cigar, or sausage shape.
Caused by membrane integrity defect.Seen in hereditary elliptocytosis, iron deficiency anemias, megaloblastic anemia, thalassemia, and sickle cell anemia.
E)reticulocytosis
Normal range 05 to 2.5%
Father has 3%
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