You work for a pharmaceutical company where you are assigned the task of creatin

Question

You work for a pharmaceutical company where you are assigned the task of creating new drug therapies to treat thyroid disorders such as hyperthyroidism (high levels of T3 and T4) and hypothyroidism (low levels of T3 and T4). Your team has designed a few drugs, and your job is to identify which drug(s) would be successful in treating thyroid disorders based on your knowledge of thyroid hormone synthesis. Below is the list of drugs your team designed (all of these are hypothetical drugs).

Peroxidine: A drug that inhibits thyroid peroxidase from functioning

Cimigine: A drug that inhibits potassium/iodine cotransporter

Iodimine: A drug that inhibits iodinase from functioning

Aldosine: A drug that inhibits production of angiotensinogen from the liver

Aldoramine: A drug that inhibits sodium/iodine cotransporter

Thyromine: A drug that stimulates thyroglobulin production

Identify the drug(s) that would be successful in treating hyperthyroidism and hypothyroidism, and explain why and how they would be successful.

Explanation / Answer

Ans.

Hyperthyroidism is a condition where there is overactive thyroid, producing more thyroxine hormone and the reverse is hypothyroidism.

Among the above hypothetical drugs, for treating hyperthyroidism, following drugs can be used:

Peroxidine, as this drug inhibits Thyroid peroxidase from functioning. Inhibiting peroxidase will not allow iodination of thyroglobulin and hence thyroxine (T4) will not get formed.

Aldoramine, as this drug inhibits sodium/iodine cotransporter (NIS), Iodine uptake in Thyroid is inhibited and Thyroxine is not formed as iodine is the chief component of thyroxine.

Aldosine, drug inhibits production of angiotensinogen. Normaly or idealy Deficit in Thyroid hormones influences synthesis and release of angiotensinogen. In this condition thyroxine levels are more and hence this drug will inhibit production of angiotensinogen.

For treating hypothyroidism, following drug can be used:

Thyromine, a drug that stimulates thyroglobulin production can be used. Thyroglobulin is used by the Thyroid gland to produce thyroxine and triiodothyronine.

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