This is a neuroscience question, about tectum pathway, about ephrin and Eph rece

Question

This is a neuroscience question, about tectum pathway, about ephrin and Eph receptors, so tectum has ephrin and ganglion has ephrin receptors. i have attached a slide, could anyone please tell me whats going on in the slide. how high and low levels of Eph affect the tectum and retina.

thank you

Ephrin and Eph receptors Kinases/other signaling molecules Anterior tectum not available Tectal cells have Ephrin; . Ganglion growth cones Ephrins Bi-directional signaling have Eph receptors; Complementary gradients of ligand in tectum and receptor in ganglioin growth cones. Eph P(Posterior (Nasal Actin Rho/ GAPs Retina Tectum . Inhibitory signalling Nasal Temporal (Anterial Posterial) Anterior Posterior Ephrin-A2 & Ephrin-A!5 EphA5 Migrating growth cone How would you explain this? 7 (Part 4) 12 Sinwuer Associates Inc Low Eph High Eph High Ephrin Ephrin Low

Explanation / Answer

The Eph/ephrin receptor ligand principally modifies cytoskeleton organisation and cell adhesion.

During the circuit development the subcellular segregation of mechanosensory and visual inputs the the specific regions of tectal neural dendrites in the tadpoles optic tectum which requires NMDA receptor activity. By blocking this NMDA receptors during the removing of visual set of inputs or formation of sensory circuits leads to less defined segregation and suggests a correlation based mechanism. these correlates inputs wire to form dendrites.

The different sensory inputs that are received and processed by optic tecta of birds, fish , amphibians and superior colliculus of mammals form disctinct layers across the laminar axis of their target neutrophils. In the lateral geniculate nucleus, the retinal ganglion cell input is segregated into different eye specific layers .

The nasal axons express low levels of EphA3 are less sensitive and can migrate further into posterior tectum where there are high levels of ephrin expression. In this way, the repulsion of ephA expressing retinal ganglion allows establishment of AP axis.

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