D) The following values are measured for substance [x] in a human subject. What

Question

D) The following values are measured for substance [x] in a human subject. What is the patient's [X) clearance? (15 points, show your working) Plasma [X) Urine [X] Renal creatinine clearance Urine collection 0.5 mg/d 50 mg/dl 80 ml/min 0.576L in 24hrs II). Assuming the subject in the preceding question is a normal adult, we can conclude that most likely potassium is- (2 points) Gyven renal cearanLt rate A fltered but not secreted or reabsorbed to o e 80 s, ansuer n B. secreted but not filtered or reabsorbed C. reabsorbed but not secreted or filteredparasa 40, So filtered and secreted filtered and reabsorbed IlI) What is the renal blood blow in this patient? (2 points)

Explanation / Answer

Renal clearances of the patient (x) is 40 ( moderate renal impairment) the equation os creatine urine/ creatine serumx volume of urine(ml)/time(hours)x60. generally for an healthy adult clearance is 80-120ml/min, ll) the potassium most likely filtered and reabsorbed here in normal adult, because potassium is less than gfr. lll)the renal blood flow in this patient: normally renal blood flow is the volume of blood delivered to the kidneys per unit time, change in rbf changes glomerular filtration rate,but in kidneys there is auto regulation and the intrinsic control renal blood flow, here in this patient there is moderate renal impairment so the renal blood flow is not affected.

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