It was a cold winter morning and Jack decided to let the car warm up in the gara

Question

It was a cold winter morning and Jack decided to let the car warm up in the garage before going off to work. About 40 minutes later, his wife was taking garbage to the garage and found him slumped over, breathing rapidly, and very confused. He was taken to hospital where he was diagnosed with acute carbon monoxide poisoning. When a blood sample was taken, his wife noted that it was a deep cherry red colour. His initial treatment was breathing 100% O2. I. Jack's O2 saturation was reduced to 50%, why? How does carbon monoxide poisoning affect the O2-dissociation curve? What else can have this effect? 3. How does carbon monoxide affect the ability of the blood to carry oxygen and why? 4. What is the rationale for treating carbon monoxide poisoning with 100% O2? Is this appropriate? 5. When admitted, Jack's arterial PO2 would have been decreased. How would it have changed while breathing 100% O2 6. What are the consequences of carbon monoxide poisoning on O2 delivery to the tissues? 7. Outline the reflexes that account for his rapid breathing. 8. What is the significance of the cherry-red coloured blood? 2.

Explanation / Answer

1) CO decreases the solubility of the oxygen in blood thus, the percent saturation. In the presence of carbon monooxide hemoglobin binds with CO preferencially.

2) CO poisioning shifts the heamoglobin (Hb) oxygen dissociation curve right side which shows high dissociation of Hb to oxygen.

3) When hemoglobin binds CO, it binds so tightly that it will not let go. Therefore, the hemoglobin that binds CO becomes 'poisoned' and can no longer bind oxygen, destroying its function. Then, parts of your body do not receive the essential oxygen, and effectively suffocate. It also altered the distribution of oxygen.

4) When a patient is given 100% oxygen under pressure, hemoglobin is saturated, but the blood can be hyperoxygenated by dissolving oxygen within the plasma. However 100% saturation of Hb with oxygen doesn't happens due to previously bind with CO.

5) Partial pressure of oxygen is the atmospheric pressure of oxygen which goes inside the alveloi but in the presence of CO the partial pressure get changed inside the blood at which Hb binds with oxygen. It is due to presence of other gas (CO).

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