Please select the best answer option for each part. Part A . Which one of the fo

Question

Please select the best answer option for each part.

Part A. Which one of the following statements concerning malignant hyperthermia is correct?

a. Excessive heat generation during an MH episode results from increased rates of metabolism and myosin ATPase activity.

b. During a malignant hyperthermia episode, the SR calcium ATPase adequately lowers myoplasmic calcium to normal resting levels.

c. Muscles from malignant hyperthermia susceptible individuals have a decreased sensitivity to halothane- and caffeine-induced contracture in vitro and in vivo.

d. During a malignant hyperthermia episode whole body oxygen consumption increases, while lactate production and carbon dioxide production all decrease.

Part B. Which one of the following statements concerning muscle diseases is incorrect?

a. Brody syndrome is the term used to describe conditions of prolonged muscle relaxation not attributable to SERCA1 gene mutations.

b. Brody’s disease is the term used to describe conditions of prolonged muscle relaxation that is attributable to SERCA1 gene mutations.

c. Dynamin proteins generate GLUT4-containing membrane vesicles in the myoplasm, and their deficiency is responsible for the abnormal glucose metabolism in certain breeds of dog.

d. The temperature-induced paralysis of fruit flies discussed in class is caused by a mutation affecting the production of synaptic vesicles.

Part C. Which one of the following statements concerning muscle diseases is correct?

a. Charcot Marie Tooth disease is a group of related genetic disorders caused by progressive and excessive over-myelination of peripheral nerve axons.

b. Myasthenia gravis results from an immune-mediated loss of functional dihydropyridine receptors at the neuromuscular junction, which in turn impairs activation of muscle sarcolemma depolarization.

c. Mutations in the RYR2 gene have never been found to be associated with diseases affecting contractility.

d. Muscle contractile activity occurring independently of normal voluntary excitation-contraction coupling is termed a contracture.

Explanation / Answer

Part A: C) Decreased sensitivity to halothane and caffeine

Part B: B) Muscle relaxation attributable to SERCA1 gene mutation.

Part C: D) Contracture

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