Please select the best option for each part. Part A. Which of the following tech

Question

Please select the best option for each part.

Part A. Which of the following techniques has yielded near-atomic resolution of an RyR channel?

a) FRET

b) super-resolution microscopy

c) single-channel gating measurement

d) [3H]ryanodine binding

e) cryo-electron microscopy (cryo-EM)

Part B. Which of the isoforms below are directly involved in skeletal muscle EC-coupling?

a) SERCA1a and SERCA2a

b) Cav1.1 and RyR1

c) Cav1.2 and RyR2

d) SERCA2a and SERCA2b

e) Cav2.1 and RyR2

Part C. Which of the isoforms below are directly involved in cardiac muscle EC-coupling?

a) SERCA1a and SERCA2a

b) Cav1.1 and RyR1

c) Cav1.2 and RyR2

d) SERCA2a and SERCA2b

e) Cav2.1 and RyR2

Explanation / Answer

Part A: answer e : cryo electron microscopy is used for near atomic resolution of RyR channels.

Part B: answer b: The isoforms directly involved in EC coupling in skeletal muscles are Cav 1.1 and RyR1.

Part C: answer c: The isoforms directly involved in EC coupling in heart muscles are Cav 1.2 and RyR2

Cav1.2 : These are ligand gated calcium channels which regulate the influx of calcium into the cells

RyR: These are called as Ryanodine receptors which are high conductance intracellular calcium channels. There are 3 isoforms available. RyR1 which is located mainly in skeletal muscles and RyR2 which are located mainly in heart muscles and RyR3 which are distributed throughout the body in different organs.

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