Please select the best answer of the 5 options for each part and please give a s

ID: 3511318 • Letter: P

Question

Please select the best answer of the 5 options for each part and please give a small explanation why.

Part A. The drug PTC124 (Ataluren)

a) It alters DNA replication.

b) It alters transcription of mRNA.

c) It alters splicing of mRNA.

d) It alters translation of mRNA.

e) It alters protein stability and folding.

Part B. The drug PTC124 (Ataluren)

a) It corrects all mutations that cause Duchenne muscular dystrophy (DMD)

b) It is a close structural homologue of gentamycin (G418).

c) It reads through all stop codons equally well.

d) It the only therapy approved by the FDA for treatment of DMD in humans.

e) None are true.

Part C. Which of the following is NOT typically measured in the mdx mouse to assess whether a drug may be an effective therapy for DMD?

a) Serum creatine kinase activity.

b) Eccentric contraction-induced force drop.

c) 6 minute walk.

d) The percentage of centrally-nucleated fibers.

e) All of the above are true.

Ataluren also called as PTC 124 is a drug for muscular dystrophy.

Part A

The answer is it alters transcription of mRNA

Part B

The answer is it corrects the mutation that cause DMD

Part C

All of the above is true.

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