Neostigmine, an acetylcholinesterase inhibitor, is introduced to the neuromuscul

Question

Neostigmine, an acetylcholinesterase inhibitor, is introduced to the neuromuscular junction. What effect would this have on the myofiber the junction innervates?

4. Why is calsequestrin essential to the cross-bridge cycle?

5. Why do you think slow and fast-twitch fibers have different isoforms of SERCA?

6. Why is the peak force at tetany higher than the peak force of a twitch?

7. How does the liver help in the energy supply of muscle during exercise?

8. What are the characteristics of type I, type IIa, and type IIb muscles?

9. What happens if ATP is not regenerated during muscle contraction?

10. What causes fatigue at low intensity and long duration?

Explanation / Answer

Neostigmine, an acetylcholinesterase inhibitor, is introduced to the neuromuscular junction causes decrese in the amount of acetylcholine receptor sites as a result of disorganisation of the postsynaptic muscle membrane, which may leads to muscular weakness associated with the long term use of anticholinesterase agents

4.Cross-bridges cycle continues Ca++ is present in the cytosol.Ca++ is actively transported back into the sarcoplasmic reticulum when there is no longer an action potential.In the SR, Ca++ is bound to calsequestrin.Troponin-Tropomyosin complex slips back over the myosin-binding site on the actin. The myosin and actin can no longer interact at the cross-bridges.Thin filaments slide back to their resting potential.

5.

6. The peak force of tetany is higher than peak force of twitch as tetanization includes the summation of twitches which causes higher force. A second action potential can be elicited before Ca++ falls to resting level. The mechanical response is increased as the 2nd twitch sums with the first.

7.The body can store some of these fuels in a form that offers muscles an immediate source of energy. ... Glucose can be used immediately as fuel, or can be sent to the liver and muscles and stored as glycogen. During exercise, muscle glycogen is converted back into glucose, which only the musclefibers can use as fuel.

8. Liver produces glucose by the process of both breakdown of glycogen (glycogenolysis) and glucose synthesis (gluconeogenesis).Glucose is the main source of energy for brain and muscles

9. Glycolysis and cellular respiration produses Adenosine Triphosphate (ATP). ... Several processes like active transport, cellular respiration, electron transport chain, and other cellular processes which include ATP as pre-requisite, would not work if ATP is not regenerated during muscular contractions.

10.The accumulation of hydrogen ions during exercises causes decrease in the activities of calcium during muscular contractions which causes fatigue.

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