Your 80 year-old great aunt, Persis, was placing a canning jar on the top shelf

Question

Your 80 year-old great aunt, Persis, was placing a canning jar on the top shelf of her pantry when she stepped awkwardly off the stool and twisted her leg at the hip. She felt a sharp pain in her hip and, after collapsing to the floor, found she could no longer stand. She was taken to the emergency room where an X ray showed that the neck of her femur was fractured. More detailed X ray images revealed reduced bone mass in the head and neck regions of the injured femur, in the ends of other long bones of the body and in the vertebrae. Surgery was necessary to repair the fractured femur and a biopsy of the bone tissue indicated that the composition of the osteoid was normal. Healing of the fractured femur is proceeding slowly.

5b. What normally happens to the microanatomy of the specific tissue you identified as it ages?

   6. What age-related alterations in the activities of the cells you identified cause this change in microanatomy?

   7. What is the significance of your great aunt being a woman?

   8. What disease caused the abnormal anatomical symptoms and led to the fracture?

   Underline one: Osteoporosis or Paget's disease (osteitis deformans)

   9. What aspects of the above description help you distinguish these two possibilities? Explain.

10. What notable anatomical features do the diseased locations have in common?

   11. Choose a therapy that is listed in your text and explain how it works to prevent this

   disease.

   [If modification of the diet is suggested, which of the basic four food groups would you recommend increasing consumption?]

Explanation / Answer

The condition is due to osteoporosis.

5--the trabeculae becomes thin and are disconnected from each other.The cortex becomes thin and porous

6-as age progresses there is increase in resorptive activity I.e the activity of osteoclast

7-she is at menopause in which estrogen levels are low which causes low bone density

8-osteoporosis led to this fracture

9-osteoporosis is due to bone loss and it dnt cause symptoms.

Paget's disease is due to increased bone turnover and causes longer bones.it may also cause symptoms like pain.but it responds well to treatment

10-weight bearing bones or bones that are subjected to stress undergo osteoporosis

11- Bisphosphonates are usd to treat this condition.it increases the osteoblastic activity and decreases the osteoclastic activity

Diet rich in calcium like diary products should be consumed

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