Problem Set / Case Study #3 I. A nerve cell has an axon that extends 3 cm with a

Question

Problem Set / Case Study #3 I. A nerve cell has an axon that extends 3 cm with an inter-node spacing or2 mm.- Calculate the membrane potential at a node just prior to the generation of an action potential given the following information: Membrane length constant = 1 mm Threshold- -35 mV Resting membrane potential (RMP)- -60 mV Action potential overshoot = +20 mV. What is the membrane potential at the next node, and is depolarization sufficient to generate another action potential? % Response-100(1-e-v.) a. -49 mV, and an AP will NOT occur at node 2 b. -30 mV, and an AP WILL occur at node 2 c. -69 mV, and an AP WILL occur at node 2 d. -25 mV, and an AP will NOT occur at node 2 2. Explain how the length constant is affected following degradation of the myelin sheath, or in other words, how is the length constant affected by decreases in membrane resistance (Rm)? How does demyelination affect conduction along the axon? 3. Name one disease that causes demyelination.

Explanation / Answer

There are mylination along the axon to facilitate nerve conduction along the axon by promoting saltatory conduction. If there occurs demylination or change in length constant ,there is loss of saltatory conduction which is a type of fast conduction system of neurons.mylination is also a protection to the axons and decrease nerve injury.

Multiple Sclerosis is the most common demylinating disease worldwide.

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