Which of the following strategies would help a cancer cell to bypass the normal

Question

Which of the following strategies would help a cancer cell to bypass the normal growth control imposed by Rb and induce proliferation? Suppress expression of p16INK4A Suppress expression of Id1 Increase expression of Smad4 Increase expression of p21Cip1 Which of the following strategies would help a cancer cell to bypass the normal growth control imposed by Rb and induce proliferation? Suppress expression of p16INK4A Suppress expression of Id1 Increase expression of Smad4 Increase expression of p21Cip1 Which of the following strategies would help a cancer cell to bypass the normal growth control imposed by Rb and induce proliferation? Suppress expression of p16INK4A Suppress expression of Id1 Increase expression of Smad4 Increase expression of p21Cip1

Explanation / Answer

Answer:

Suppress expression of p16INK4A.

Explanation: The RB (Retinoblastoma ) gene located on the chromosome 13q14 is normally present in the active state in every cell. It arrests the cell cycle at the late G1 phase. Various growth factors inactivate the RB gene by phosphorylating it which removes the G1 cell cycle block allowing the cell to pass from G1/S block point and to proliferate.

The p16INK4A Tumor Suppressor Protein functions as an inhibitor of CDK4 and CDK6; which can initiate the phosphorylation of RB. Thus p16INK4A protein can arrest cells in the G1 Phase and lead to cellular senescence (irreversible growth arrest). Cellular senescence plays an important role in tumor suppression and hence, suppressing the expression of p16INK4A protein will help a cancer cell to bypass its normal regulation of cell cycle by RB and lead to excessive proliferation by removal if the G1/S cell block.

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