In newly formed neural tube, the intermediate region close to the sulcus limitan

Question

In newly formed neural tube, the intermediate region close to the sulcus limitans has been not exposed to molecules that induce ventral or dorsal characteristics. You perform explant experiments in which you take intermediate neural tube (host tissue) and culture them with donor tissue explants that induce specific spinal cord markers in the host explant.

1. The induced host tissue expresses Shh following transplant. What donor tissue have you explanted next to the host tissue, what signal is released to induce this marker, and what cell type has been induced? Briefly explain your reasoning.

Explanation / Answer

Donor tissue explanted next to the host tissue is Neural stem cell (NSCs).Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the neurons and glia of the nervous system of all animals during embryonic development. Some neural stem cells persist in the adult vertebrate brain and continue to produce neurons throughout life. Sonic Hedgehog Signaling (Shh) is the signaling in itself due to the presence of infalammation or growth required at the place of impregnation which induces host tissue for the increased neuroinflammation and regeneration asc the function of Shh is to facilitate in the preservance of the tissue endogenously

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