1. You have identified a constitutively open monovalent cation channel and wish

Question

1. You have identified a constitutively open monovalent cation channel and wish to determine its selectivity properties. A bi-ionic experiment is performed under conditions where equal molar concentrations of Na and K are placed in the extracellular and intracellular solutions respectively, and the reversal potential is found to be 0 mV. a. What would you conclude about the selectivity of this channel? b. What prediction would you make regarding the effect of this channel on the resting membrane potential of the cell if the initial membrane potential is -60 mV and this cation channel is activated? Explain.

Explanation / Answer

Answer constitutively open channel is Na channel. Because intracellular Na concentration is low as compared to extracellular.

Na movement from outside to inside creates membrane potential 0.

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