The nephron is the functional unit of the kidney. Fluid enters the space within

Question

The nephron is the functional unit of the kidney. Fluid enters the space within Bowman's capsule through filtration across the glomerular capillaries. The walls of these capillaries will allow small ions and other solutes to pass from the plasma phase of the blood to the filtrate in Bowman's capsule. However, proteins are too big to cross the capillary and these are retained within the capillaries. Estimate the total glomerular filtration rate (GFR) if the average glomerular pressure is 60 mmHg and the pressure within the Bowman's cap- sule that collects the filtrate is 20 mmHg. The osmotic pressure of the retained plasma proteins is 25.6 mmHg. The value of L,S for the glomerular capillaries is about 8.7 mL min-1 mmHg-1

Explanation / Answer

GFR is defined as the fluid flow rate between glomerular capillaries and bowmans capsule.

GFR = Kf x ( Pg - Pb - IIg + IIb)

Kf = filteration constant

Pg= Hydrostatic pressure within glomerular capillary

Pb= hydrostatic pressure within bowmans capsule

IIg= Colloid osmotic pressure within glomerular capillary

IIb= colloid osmotic pressure within glomerular capillary

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