You\'ve discovered a new signaling molecule. Upon molecular examination you real

Question

You've discovered a new signaling molecule. Upon molecular examination you realize that 80% of the molecule is lipophilic. Additionally the molecule is quite small. Your next set of experiments will be to try to find the receptor for this hormone. Which of the following is the best experimental approach?

A. To purify cell membranes and look among the proteins embedded within to find the receptor

B. To purify the proteins found inside the cell to find the receptor

I am confused on how you know if its an intracellular or cell surface receptor

Explanation / Answer

The human steroid hormones and thyroxine are highly lipophilic and small in size, that cross the plasma membrane.

The more lipophilic a molecule is , the easier it can cross the plasma lipid bilayer of the cell, , because the plasma membrane is made up of PLLP (protein-lipid-lipid-protein) layers.

I think 80 % lipophilicity and the small size of molecule will enable it to cross the cell membrane and hence more likely, the receptor will be found inside the cell.

I would go with option( B)

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