In Rett Syndrome (RTT), deficiencies often arise due to improper synaptic signal

Question

In Rett Syndrome (RTT), deficiencies often arise due to improper synaptic signaling (or loss of synaptic signaling). Describe what happens at a normal chemical (neurotransmitter) synapse (not an RTT synapse). Assume the NT that is released is glutamate, and that it is excitatory. Include:

Arrival of AP at pre-synapse—which channels open?

Mechanism of vesicle docking and NT release

Post-synaptic receptor binding—what happens in the post-synaptic cell to initiate a GP?

GP --> AP in post-synaptic neuron

Explanation / Answer

Chemical synapse is a junction through neurons signals can be exchanged to each other and to non-neuronal cells. At a chemical synapse, one neuron releases neurotransmitter molecules in to the synaptic cleft. These molecules then bind to neurotransmitter receptors on the postsynaptic cells's side of the synaptic cleft.

Arrival of AP at pre-synapse-- Na+ and K+ channels.

Post-synaptic receptor binding-opens the ion channels to initiate graded potential.

GP (Graded potential ) initiates AP in post-synaptic neuron

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