Oxygen (O2) is normally carried bound to hemoglobin within red blood cells, and

Question

Oxygen (O2) is normally carried bound to hemoglobin within red blood cells, and the toxic gas carbon monoxide (CO) can competitively bind to the same binding sites. The graph below demonstrates the effect of CO on the binding of oxygen to hemoglobin Analyze these data, and click on each box at right containing a correct conclusion CO binds to hemoglobin with higher affinity than oxygen Hemoglobin binding sites are saturated at a lower O level in the presence of CO 100 80 No CO present If the CO level was 5 mmHg and the O, level was 100 mmHg, more than 50% of hemoglobin binding sites would have O, bound 60 Pco present at 0.5 mmHg Hemoglobin has a higher affinity for O2 when CO is present. 20 O, binds to hemoglobin with higher affinity than CO 0 20 40 60 80 100 120 140 Po2 (mmHg) Hemoglobin has a lower affinity for O, when CO is present.

Explanation / Answer

The affinity between Carbon monoxide and Hemoglobin is 230 times more than that between oxygen and Hemoglobin.

So when Carbon monoxide and Oxygen are present more amount of Carbon monoxide will bind to hemoglobin than Oxygen.so we can coclude that,

The Boxes 1,2,3and 5 Contain the Correct Conclusion

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